Description - The Development of Iron Chelators for Clinical Use by Barry Halliwell
Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron mediated tissues damage, and it clearly outlines successes and shortcomings of current iron chelators therapy in preventing such damage. The book also describes a number of other potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron co-ordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators.
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