Seventeen-year-old Lovisa King leaves Missouri for the Oregon Territory in 1845. A Heart for Any Fate, based on the history of a company of real pioneers, tells the story of the King family, whose careful plans are challenged by the harsh, unforeseen realities of overland travel. The family makes the unfortunate decision to follow guide Stephen Meek, who leads them into blistering weather, drought, and treacherous river crossings along a shortcut that becomes known as the Terrible Trail.