David Sloan Wilson and Denis Noble participate in a dialogue centering around the sufficiency of a neo-Darwinian framework of biology. Does neo-Darwinism provide a reasonably complete and adequate explanation of biological phenomena? Are there any new theoretical breakthroughs that are necessary to support the framework? The point of this dialogue is for both parties to advance the best case for their position, as well as to refute the case of their Interlocutor.