The kind of life associated with primitive man involved a scarcity of food and salt, irregularity of feeding, seasonal and geographical variation of food, nomadic life, in which walking was the main form of exercise and sudden outbursts of energy either to catch prey or to avoid being prey. Life was organized in a small-group, structured social style. Contact among groups was limited. Now we control our world in a period of de-evolution, changing the rules of the game. We shape the world instead of the world shaping us. We have plenty of food and regular "social" feeding even when we do not it; there is static life (watching television) and there is no sudden use of high levels of energy; there are too many people everywhere, too many contacts, causing stress and confusion in our life. The pristine playgrounds, just small patches, still survive in some places in Africa to explain the real evolutionary playground for us and our real nature. We cannot go back, but knowing who we are will help us to survive better and to create a better world according to our real evolutionary plan. This is a study of the evolution of vascular diseases and man's adjustment to them.