After small-time mobster Joe D'Amato gets attacked by a werewolf, his life takes a dark turn and he begins a transformation towards a new, twisted life.

When corpses start piling up, two cops suspect there is something unnatural on the loose - and they have a suspect. When nobody listens to their theories, they go rogue and start digging for clues.

Soon, forces both natural and supernatural clash, and all hell breaks loose.