A year after getting shot on a job that took a dangerous turn, Jane has settled into the quiet life of a suburban housewife in Amherst, New York--or so she thinks. One morning, coming back from a long run, Jane is met by an unusual sight: the female leaders of the eight Seneca clans parked in her driveway in two black cars. They have come to her with an unusual request. Jane's childhood friend from the reservation is wanted by the police for the murder of a local white man, and he has fled. The clan mothers believe that Jane is the only one who can find him. So Jane sets out to retrace a journey she took with Jimmy when they were fourteen years old, and soon realizes that the police aren't the only ones after her childhood friend. As the chase intensifies, the number of people caught up in this deadly plot grows, and Jane is the only one who can protect those endangered by it.