Physiology and physiological chemistry were at one time a single field of investigation. The latter, owing to the remarkable progress of the exact sciences chemistry and physics, has now developed to such an impor tant branch of natural science that it is altogether impossible today for any one scientist to master thoroughly in all its details the whole field of physiology. Little by little, there has developed a sharp distinction between pure physiology and physiological chemistry. It is clear that an artificial separation of two such closely related fields of investiga tion must work to disadvantage for the development of each, so that it is fortunate to find it recognized more and more that the whole science of physiology can only develop satisfactorily when there is an intimate exchange of ideas between investigators in the two fields. The chemical decompositions in the tissues do not take place beside the physiological processes, but are bound up with them. In no single case can we carry out any distinction-in such a sense; and with those organs in which the relations between the functions and the metabolism are not known, this is chiefly because of our limited knowledge concerning the latter. In this connection we need only recall the whole nervous system.

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