While Abel travels the arid West in the company of Lilith and bows to her desires, the men of the terrible Colonel capture them. The latter wants to appease his anger and punish them before heading back to Holy Island and its golden menhirs...

Meanwhile, Cain, on a desperate quest to heal a young girl from a strange evil, realizes that the only hope to save her is also back on the island!

Filmmaker and writer Alejandro Jodorowsky concludes his mystical saga, inspired by his beloved cult classic film El Topo (1970), with illustrator José Ladrönn (Future State: The Next Batman), immersing us in a surreal and deeply spiritual western, where fate will bring the two sons of El Topo together for a final journey, one driven by hate, the other by love...